![]() ![]() Six months to one year later, all the physical and biochemical properties measured returned to baseline.Ĭardiovascular disease (CVD) is the most common cause of death worldwide, with the total number of CVD deaths increasing by 40% between 19 1. During the same period, the hematocrit-adjusted low shear rate viscosity increased significantly, as did the yield stress, indicating more solid-like behavior for blood. Despite lower RBC concentration, the RBC aggregate shape became larger and more rounded, which is correlated to the elevated plasma fibrinogen related to systemic inflammatory response. Within a week following surgery, the patient hematocrit was significantly lower due to CPB. We examined shear-rate dependent blood viscosity, elasticity and RBC aggregate size in the pre-surgery disease state, post-surgery state and long-term recovery state of cardiac surgical patients. We investigated blood physical properties changes and the correlation between blood microstructure, viscoelastic response and biochemical changes following surgery with CPB. However, elevated red blood cell (RBC) aggregation may lead to the common side-effects such as microinfarction. During cardiac surgery, cardiopulmonary bypass (CPB) can temporarily take over the function of heart and lungs. ![]() Open heart surgeries are common for treating ischemic and heart valve disease. ![]()
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